Charles Sentman Ph.D. '85 Associate Professor of Microbiology and Immunology Dartmouth Medical School
Brother Sentman was featured in the summer 2008 Arrow. The following is the interview from this issue.
Q: Why did you join Psi Upsilon? A: Both my father and grandfather were in fraternities at the U of I, so I decided to have a look. The brothers at Psi U were really friendly, and it seemed like a good group to join. The food was pretty good too. When we got a cook who would read and follow the recipes, it got even better!
Q: What do you do for a living? A: I finished a B.S. in biochemistry at Illinois, and then I did a Ph.D. in Immu- nology at UT Southwestern Medical Center in Dallas. After two years of postdoctoral training at Washington Uni- versity in St. Louis, I received an Ameri- can Cancer Society fellowship to go to the Karolinska Institute in Stockholm, Sweden. I moved over to Sweden in 1992 and stayed there for over 9 years. I held positions in both academia and the pharmaceutical industry while in Swe- den. In 2001, I accepted a job on the faculty at Dartmouth Medical School in New Hampshire. I conduct research on how the immune system works in re- sponse to cancer and infection. I also teach medical and graduate students about immunology and tumor biology.
Q: What are your goals for the next few years? A: One of our latest projects is the de- velopment of a new immunotherapy for cancer, called chimeric NK cell recep- tors.
We put these novel receptors in a pa- tient’s blood cells and this allows the cells to recognize and attack their own tumor cells. Because these engineered cells now recognize molecules common to cancers but not normal cells, they have the potential to be used against a wide variety of cancers, including ovar- ian, breast, prostate, colon, liver, kidney, lymphoma, and myeloma. We have had good success using samples from ovar- ian cancer and myeloma patients, and we have found long-term, tumor-free survival in animal tumor models. One important aspect of this approach is that the cells not only attack the tumor, but they induce the rest of the immune sys- tem to recognize and attack the tumor cells in a specific manner. This results in the complete eradication of the tumor. We are currently investigating the de- tails of how these receptors work, and we are looking forward to conducting a phase I clinical trial at some point in the future. However, as the government has cut back on research funding during these past years, it has become more challenging to keep moving forward and test new ideas.
Q: Tell us about your family? A: In Sweden, I met and married a won- derful woman, Mia. We now have three daughters; they are eight years, five years, and nine months old. Fortunately, the girls all look a lot like their mother! We really like small town New England life. This town gets six feet of annual snowfall, and there are plenty of oppor- tunities for skiing, skating and hiking in the nearby White and Green mountains.
Q: What are some of your favorite memories from your fraternity days? A: There was a lot of Foosball, and we played backgammon too. During finals week, we sometimes rented a VCR along with movies like “Raiders of the Lost Ark” or “Caddyshack.” OK, maybe it wasn’t the best thing for the house GPA, but it was nice to take a break from studying now and then.
Q: What positions did you hold while in the house? A: I was Rush chairman together with Larry Rakers ‘86. We did really well with informal Rush, better than the more formal Rush weekend. As candidates came over and had time to meet with the guys in a regular setting, they really liked who they met and many of them decided to pledge Psi U. Membership went up and down, but the house was mostly full during the time I was there.
Q: With whom from the chapter do you stay in contact? A: I have stayed in contact with Frank Markus ‘86 and Fermin Návar ‘87.5 over the years. When I moved to Swe- den, I sort of dropped off the radar screen and didn’t travel through the U.S. much during that time. A few people have found me via the Internet, and it is nice to hear from them again.
Q: What rooms did you live in the house? A: I lived in the Beta Chi, in the room above the Owl, and in the third floor facing the Armory. |